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Molecular clouds (MCs) are active sites of star formation in galaxies, and their formation and evolution are largely affected by stellar feedback. This includes outflows and winds from newly formed stars, radiation from young clusters, and supernova explosions. High-resolution molecular line observations allow for the identification of individual star-forming regions and the study of their integrated properties. Moreover, state-of-the-art simulations are now capable of accurately replicating the evolution of MCs, including all key stellar feedback processes. We present¹³CO(2–1) synthetic observations of the STARFORGE simulations produced using the radiative transfer code RADMC-3D, matching the observational setup of the SEDIGISM survey. From these synthetic observations, we identified the population of MCs using hierarchical clustering and analysed them to provide insights into the interpretation of observed MCs as they evolve. The flux distributions of the post-processed synthetic observations and the properties of the MCs, namely, radius, mass, velocity dispersion, virial parameter, and surface density, are consistent with those of SEDIGISM. Both samples of MCs occupy the same regions in the scaling relation plots; however, the average distributions of MCs at different evolutionary stages do not overlap on the plots. This highlights the reliability of our approach in modelling SEDIGISM and suggests that MCs at different evolutionary stages contribute to the scatter in observed scaling relations. We study the trends in MC properties, morphologies, and fragmentation over time to analyse their physical structure as they form, evolve, and are destroyed. MCs appear as small diffuse cloudlets in early stages, and this is followed by their evolution to filamentary structures before being shaped by stellar feedback into 3D bubbles and getting dispersed. These trends in the observable properties of MCs are consistent with other realisations of simulations and provide strong evidence that clouds exhibit distinct morphologies over the course of their evolution. 

Context. The ionization feedback from H  II regions modifies the properties of high-mass starless clumps (HMSCs, of several hundred to a few thousand solar masses with a typical size of 0.1–1 pc), such as dust temperature and turbulence, on the clump scale. The question of whether the presence of H  II regions modifies the core-scale (~0.025 pc) fragmentation and star formation in HMSCs remains to be explored. Aims. We aim to investigate the difference of 0.025 pc-scale fragmentation between candidate HMSCs that are strongly impacted by H  II regions and less disturbed ones. We also search for evidence of mass shaping and induced star formation in the impacted candidate HMSCs. Methods. Using the ALMA 1.3 mm continuum, with a typical angular resolution of 1.3′′, we imaged eight candidate HMSCs, including four impacted by H  II regions and another four situated in the quiet environment. The less-impacted candidate HMSCs are selected on the basis of their similar mass and distance compared to the impacted ones to avoid any possible bias linked to these parameters. We carried out a comparison between the two types of candidate HMSCs. We used multi-wavelength data to analyze the interaction between H  II regions and the impacted candidate HMSCs. Results. A total of 51 cores were detected in eight clumps, with three to nine cores for each clump. Within our limited sample, we did not find a clear difference in the ~0.025 pc-scale fragmentation between impacted and non-impacted candidate HMSCs, even though H  II regions seem to affect the spatial distribution of the fragmented cores. Both types of candidate HMSCs present a thermal fragmentation with two-level hierarchical features at the clump thermal Jeans length λ J,clump th and 0.3 λ J,clump th . The ALMA emission morphology of the impacted candidate HMSCs AGAL010.214-00.306 and AGAL018.931-00.029 sheds light on the capacities of H  II regions to shape gas and dust in their surroundings and possibly to trigger star formation at ~0.025 pc-scale in candidate HMSCs. Conclusions. The fragmentation at ~0.025 pc scale for both types of candidate HMSCs is likely to be thermal-dominant, meanwhile H  II regions probably have the capacity to assist in the formation of dense structures in the impacted candidate HMSCs. Future ALMA imaging surveys covering a large number of impacted candidate HMSCs with high turbulence levels are needed to confirm the trend of fragmentation indicated in this study.